G protein coupled receptor 30 (GPER1) Human Gene Knockout Kit (CRISPR)

CAT#: KN203027RB

GPER1 - human gene knockout kit via CRISPR, HDR mediated




 HDR-mediated knockout kit validation

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CNY 12,260.00


货期*
6周

规格
    • 1 kit

Product images

经常一起买 (3)
pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
    • 10 ug

CNY 3,710.00


Rabbit Polyclonal Anti-GPER1 Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


Lenti ORF particles, GPER1 (Myc-DDK tagged) - Human G protein-coupled estrogen receptor 1 (GPER), transcript variant 3, 200ul, >10^7 TU/mL
    • 200 ul

CNY 8,930.00

Specifications

Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Donor DNA RFP-BSD
Symbol G protein coupled receptor 30
Locus ID 2852
Kit Components

KN203027G1, G protein coupled receptor 30 gRNA vector 1 in pCas-Guide CRISPR vector

KN203027G2, G protein coupled receptor 30 gRNA vector 2 in pCas-Guide CRISPR vector

KN203027RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001031682, NM_001039966, NM_001098201, NM_001505
Synonyms CMKRL2; FEG-1; GPCR-Br; LERGU; LERGU2; MGC99678
Summary This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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