COX11 Human Gene Knockout Kit (CRISPR)
CAT#: KN203238LP
COX11 - human gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
CNY 3,710.00
CNY 2,400.00
CNY 3,990.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
Donor DNA | Luciferase-Puro |
Symbol | COX11 |
Locus ID | 1353 |
Kit Components |
KN203238G1, COX11 gRNA vector 1 in pCas-Guide CRISPR vector KN203238G2, COX11 gRNA vector 2 in pCas-Guide CRISPR vector KN203238LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001162861, NM_001162862, NM_001321518, NM_004375, NR_027941, NR_027942, NR_135677 |
Synonyms | COX11P |
Summary | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009] |
Documents
Product Manuals |
FAQs |
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN203238 | COX11 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN203238BN | COX11 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN203238RB | COX11 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN403238 | COX11 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
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GA100944 | COX11 CRISPRa kit - CRISPR gene activation of human cytochrome c oxidase copper chaperone COX11 |
CNY 12,255.00 |