Acetyl CoA synthetase (ACSS2) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA	Luciferase-Puro
Symbol	Acetyl CoA synthetase
Locus ID	55902
Kit Components	KN204260G1, Acetyl CoA synthetase gRNA vector 1 in pCas-Guide CRISPR vector KN204260G2, Acetyl CoA synthetase gRNA vector 2 in pCas-Guide CRISPR vector KN204260LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001076552, NM_001242393, NM_018677, NM_139274, NR_028046
Synonyms	ACAS2; ACECS; ACS; ACSA; dJ1161H23.1
Summary	This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

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