Tcim Mouse Gene Knockout Kit (CRISPR)
CAT#: KN300185LP
1810011O10Rik - mouse gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
Donor DNA | Luciferase-Puro |
Symbol | Tcim |
Locus ID | 69068 |
Kit Components |
KN300185G1, Tcim gRNA vector 1 in pCas-Guide CRISPR vector KN300185G2, Tcim gRNA vector 2 in pCas-Guide CRISPR vector KN300185LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_026931 |
Synonyms | 1110065B09Rik; AW121743; AW321058 |
Summary | Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (PubMed:24937306). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity).[UniProtKB/Swiss-Prot Function] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN300185 | 1810011O10Rik - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN300185BN | 1810011O10Rik - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN300185RB | 1810011O10Rik - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN500185 | 1810011O10Rik - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
|
GA208041 | Tcim CRISPRa kit - CRISPR gene activation of mouse transcriptional and immune response regulator |
CNY 12,255.00 |