Selenop Mouse Gene Knockout Kit (CRISPR)
CAT#: KN315523BN
Sepp1 - mouse gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
CNY 3,710.00
CNY 3,184.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | Selenop |
Locus ID | 20363 |
Kit Components |
KN315523G1, Selenop gRNA vector 1 in pCas-Guide CRISPR vector KN315523G2, Selenop gRNA vector 2 in pCas-Guide CRISPR vector KN315523BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001042613, NM_001042614, NM_009155 |
Synonyms | AU018766; D15Ucla1; Se-P; selp; Sepp1 |
Summary | This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017] |
Documents
Product Manuals |
FAQs |
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN315523 | Selenop - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN315523LP | Sepp1 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN315523RB | Sepp1 - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN515523 | Sepp1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
|
GA203847 | Selenop CRISPRa kit - CRISPR gene activation of mouse selenoprotein P |
CNY 12,255.00 |
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