Aconitase 1 (ACO1) (NM_002197) Human Mass Spec Standard

CAT#: PH301857

ACO1 MS Standard C13 and N15-labeled recombinant protein (NP_002188)



  View other "Aconitase 1" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of aconitase 1, soluble (ACO1)
    • 100 ug

CNY 3,080.00


Rabbit Polyclonal Anti-ACO1 Antibody
    • 50 ug

CNY 4,628.00

Specifications

Product Data
Description ACO1 MS Standard C13 and N15-labeled recombinant protein (NP_002188)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC201857
Predicted MW 98.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_002188
RefSeq Size 3561
RefSeq ORF 2667
Synonyms ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
Locus ID 48
Cytogenetics 9p21.1
Summary The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
Protein Families Druggable Genome
Protein Pathways Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Metabolic pathways
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