Endothelin 1 (EDN1) (NM_001955) Human Mass Spec Standard

Specifications

Product Data
Description	EDN1 MS Standard C13 and N15-labeled recombinant protein (NP_001946)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202217
Predicted MW	24.4 kDa
Protein Sequence	Sequence Link (showhide) >RC202217 protein sequence Red=Cloning site Green=Tags(s) MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLD IIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWN NHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGNPSRERYVTHNRA HW TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001946
RefSeq Size	2112
RefSeq ORF	636
Synonyms	ARCND3; ET1; HDLCQ7; PPET1; QME
Locus ID	1906
Cytogenetics	6p24.1
Summary	This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Melanogenesis

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