WIBG (PYM1) (NM_032345) Human Mass Spec Standard

CAT#: PH302988

WIBG MS Standard C13 and N15-labeled recombinant protein (NP_115721)



  View other "WIBG" proteins (8)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description WIBG MS Standard C13 and N15-labeled recombinant protein (NP_115721)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC202988
Predicted MW 22.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_115721
RefSeq Size 1244
RefSeq ORF 612
Synonyms PYM; WIBG
Locus ID 84305
Cytogenetics 12q13.2
Summary Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.[UniProtKB/Swiss-Prot Function]
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