Cystatin A (CSTA) (NM_005213) Human Mass Spec Standard

Specifications

Product Data
Description	CSTA MS Standard C13 and N15-labeled recombinant protein (NP_005204)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203115
Predicted MW	11 kDa
Protein Sequence	Sequence Link (showhide) >RC203115 protein sequence Red=Cloning site Green=Tags(s) MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYMHLKVF KSLPGQNEDLVLTGYQVDKNKDDELTGF TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_005204
RefSeq Size	838
RefSeq ORF	294
Synonyms	AREI; PSS4; STF1; STFA
Locus ID	1475
Cytogenetics	3q21.1
Summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]

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