SH2D1A (NM_002351) Human Mass Spec Standard
CAT#: PH304723
SH2D1A MS Standard C13 and N15-labeled recombinant protein (NP_002342)
View other "SH2D1A" proteins (4)
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CNY 19,520.00
Specifications
Product Data | |
Description | SH2D1A MS Standard C13 and N15-labeled recombinant protein (NP_002342) |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence | RC204723 |
Predicted MW | 14.2 kDa |
Protein Sequence |
>RC204723 protein sequence
Red=Cloning site Green=Tags(s) MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAP GVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Labeling Method | Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
Reference Data | |
RefSeq | NP_002342 |
RefSeq Size | 2523 |
RefSeq ORF | 384 |
Synonyms | DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; XLP; XLPD; XLPD1 |
Locus ID | 4068 |
Cytogenetics | Xq25 |
Summary | This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Protein Pathways | Natural killer cell mediated cytotoxicity |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400845 | SH2D1A HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY400845 | Transient overexpression lysate of SH2 domain protein 1A (SH2D1A), transcript variant 1 |
CNY 3,080.00 |
|
TP304723 | Recombinant protein of human SH2 domain protein 1A (SH2D1A), transcript variant 1, 20 µg |
CNY 2,900.00 |
|
TP720893 | Purified recombinant protein of Human SH2 domain containing 1A (SH2D1A), transcript variant 1 |
CNY 3,140.00 |