SH2D1A (NM_002351) Human Recombinant Protein
CAT#: TP304723
Recombinant protein of human SH2 domain protein 1A (SH2D1A), transcript variant 1, 20 µg
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
>RC204723 protein sequence
Red=Cloning site Green=Tags(s) MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAP GVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Tag | C-Myc/DDK |
Predicted MW | 14 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_002342 |
Locus ID | 4068 |
UniProt ID | O60880 |
Refseq Size | 2523 |
Cytogenetics | Xq25 |
Refseq ORF | 384 |
Synonyms | DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; XLP; XLPD; XLPD1 |
Summary | This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Protein Pathways | Natural killer cell mediated cytotoxicity |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC400845 | SH2D1A HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY400845 | Transient overexpression lysate of SH2 domain protein 1A (SH2D1A), transcript variant 1 |
CNY 3,080.00 |
|
PH304723 | SH2D1A MS Standard C13 and N15-labeled recombinant protein (NP_002342) |
CNY 19,520.00 |
|
TP720893 | Purified recombinant protein of Human SH2 domain containing 1A (SH2D1A), transcript variant 1 |
CNY 3,140.00 |