TWIST2 (NM_057179) Human Mass Spec Standard

Specifications

Product Data
Description	TWIST2 MS Standard C13 and N15-labeled recombinant protein (NP_476527)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC205006
Predicted MW	18.1 kDa
Protein Sequence	Sequence Link (showhide) >RC205006 protein sequence Red=Cloning site Green=Tags(s) MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRIL ANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHER LSYAFSVWRMEGAWSMSASH TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_476527
RefSeq Size	1186
RefSeq ORF	480
Synonyms	AMS; BBRSAY; bHLHa39; DERMO1; FFDD3; SETLSS
Locus ID	117581
Cytogenetics	2q37.3
Summary	The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]
Protein Families	Druggable Genome, Transcription Factors

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