PKC iota (PRKCI) (NM_002740) Human Mass Spec Standard

CAT#: PH305379

PRKCI MS Standard C13 and N15-labeled recombinant protein (NP_002731)



  View other "PKC iota" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of protein kinase C, iota (PRKCI)
    • 100 ug

CNY 3,080.00


Rabbit polyclonal Anti-PRKCI Antibody
    • 100 ul

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Specifications

Product Data
Description PRKCI MS Standard C13 and N15-labeled recombinant protein (NP_002731)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC205379
Predicted MW 67.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_002731
RefSeq Size 4884
RefSeq ORF 1761
Synonyms DXS1179E; nPKC-iota; PKCI
Locus ID 5584
Cytogenetics 3q26.2
Summary This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Endocytosis, Insulin signaling pathway, Tight junction
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