PD1 (PDCD1) (NM_005018) Human Mass Spec Standard

CAT#: PH310364

PD-1 / PDCD1 MS Standard C13 and N15-labeled recombinant protein (NP_005009)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description PD-1 / PDCD1 MS Standard C13 and N15-labeled recombinant protein (NP_005009)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC210364
Predicted MW 31.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_005009
RefSeq Size 2115
RefSeq ORF 864
Synonyms CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Locus ID 5133
Cytogenetics 2q37.3
Summary Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), T cell receptor signaling pathway
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