COASY (NM_001042529) Human Mass Spec Standard

CAT#: PH315228

COASY MS Standard C13 and N15-labeled recombinant protein (NP_001035994)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description COASY MS Standard C13 and N15-labeled recombinant protein (NP_001035994)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC215228
Predicted MW 62.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001035994
RefSeq Size 2182
RefSeq ORF 1692
Synonyms DPCK; NBIA6; NBP; PCH12; pOV-2; PPAT; UKR1
Locus ID 80347
Cytogenetics 17q21.2
Summary Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]
Protein Pathways Metabolic pathways, Pantothenate and CoA biosynthesis
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