HIF1 beta (ARNT) (NM_178426) Human Mass Spec Standard

CAT#: PH317284

ARNT MS Standard C13 and N15-labeled recombinant protein (NP_848513)



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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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Specifications

Product Data
Description ARNT MS Standard C13 and N15-labeled recombinant protein (NP_848513)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC217284
Predicted MW 35.8 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_848513
RefSeq Size 3563
RefSeq ORF 984
Synonyms aryl hydrocarbon receptor nuclear translocator; bHLHe2; dioxin receptor, nuclear translocator; HIF-1beta; HIF1B; HIF1BETA; hypoxia-inducible factor 1, beta subunit; OTTHUMP00000032943; TANGO
Locus ID 405
Cytogenetics 1q21.3
Summary This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Pathways in cancer, Renal cell carcinoma
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