CCDC46 (CEP112) (NM_001037325) Human Mass Spec Standard

Specifications

Product Data
Description	CCDC46 MS Standard C13 and N15-labeled recombinant protein (NP_001032402)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC219337
Predicted MW	24.4 kDa
Protein Sequence	Sequence Link (showhide) >RC219337 representing NM_001037325 Red=Cloning site Green=Tags(s) MWASLSLDHPSAKENQALRLIEMREENGNVPKTEQAGSLKPLRDTGKSNLKEKKANSKLKQIEKEYTQKL AKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRC AEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQGR R TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001032402
RefSeq Size	1258
RefSeq ORF	633
Synonyms	CCDC46; MACOCO; SPGF44
Locus ID	201134
Cytogenetics	17q24.1
Summary	This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

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