TRAF4AF1 (KNSTRN) (NM_033286) Human Mass Spec Standard

CAT#: PH322981

C15orf23 MS Standard C13 and N15-labeled recombinant protein (NP_150628)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Rabbit Polyclonal Anti-KNSTRN Antibody
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Transient overexpression lysate of chromosome 15 open reading frame 23 (C15orf23), transcript variant 3
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Description C15orf23 MS Standard C13 and N15-labeled recombinant protein (NP_150628)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC222981
Predicted MW 35.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_150628
RefSeq Size 1763
RefSeq ORF 948
Synonyms C15orf23; HSD11; SKAP; TRAF4AF1
Locus ID 90417
Cytogenetics 15q15.1
Summary Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).[UniProtKB/Swiss-Prot Function]
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