NUMB1 Mutant (R262W) Human Recombinant Protein

Specifications

Product Data
Description	Purified mutant recombinant protein of Human numb homolog (Drosophila) (NUMB), transcript variant 1，mutation at（R262W)
Species	Human
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	A DNA sequence from TrueORF clone, RC220960, encoding the full-length of NUMB(S413A)
Tag	Myc-DDK
Predicted MW	70.6 kDa
Concentration	>0.05 µg/µL as determined by microplate Bradford method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_001005743.1
Locus ID	8650
Refseq Size	3647
Cytogenetics	14q24.2-q24.3
Refseq ORF	1953
Synonyms	C14orf41; c14_5527; S171
Summary	The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Protein Pathways	Notch signaling pathway

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