Neurofilament H (200 kD) Bovine Protein

Specifications

Product Data
Description	Neurofilament H (200 kD) bovine protein, 0.1 mg
Species	Bovine
Protein Source	Spinal Cord
Predicted MW	200 kDa
Concentration	lot specific
Purity	>98% (determined by SDS gelelectrophoresis)
Buffer	Presentation State: Purified State: Lyophilized
Reconstitution	Restore with 80 µl distilled water (final volume 100 µl). Final solution: 10mM Sodium Phosphate, pH 7.5, 2mM DTT, 6M Urea, 1 mM EDTA.
Preparation	Lyophilized
Applications	Protein standard in 1D and 2D SDS gelelectrophoresis. Immunoassays. Immunization.
Protein Description	Bovine Neurofilament 200 kDa
Note	Isoelectric Point: pI 5.5 Suitable to rebuild protofilaments and filaments under conditions of reconstitution.
Storage	Store at 2-8°C (lyophilized) or at -20°C (reconstituted). Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_066554
Locus ID	4744
Cytogenetics	22q12.2
Synonyms	NEFH,NF-H,KIAA0845, NFH, 200 kDa neurofilament protein, Neurofilament triplet H protein, (Neuronal Marker), heavy polypeptide
Summary	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
Protein Families	Protein standard in 1D and 2D SDS gelelectrophoresis. Immunoassays. Immunization.
Protein Pathways	Amyotrophic lateral sclerosis (ALS)

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