Neurofilament H (200 kD) Bovine Protein

Specifications

Product Data
Description	Neurofilament H (200 kD) bovine protein, 0.1 mg
Species	Bovine
Protein Source	Spinal Cord
Predicted MW	200 kDa
Concentration	lot specific
Purity	>98% (determined by SDS gelelectrophoresis)
Buffer	Presentation State: Purified State: Lyophilized
Reconstitution	Restore with 80 µl distilled water (final volume 100 µl). Final solution: 10mM Sodium Phosphate, pH 7.5, 2mM DTT, 6M Urea, 1 mM EDTA.
Preparation	Lyophilized
Applications	Protein standard in 1D and 2D SDS gelelectrophoresis. Immunoassays. Immunization.
Protein Description	Bovine Neurofilament 200 kDa
Note	Isoelectric Point: pI 5.5 Suitable to rebuild protofilaments and filaments under conditions of reconstitution.
Storage	Store at 2-8°C (lyophilized) or at -20°C (reconstituted). Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_066554
Locus ID	4744
Cytogenetics	22q12.2
Synonyms	CMT2CC; NFH
Summary	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]
Protein Families	Druggable Genome
Protein Pathways	Amyotrophic lateral sclerosis (ALS)

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