Neutrophil elastase Human Protein

Specifications

Product Data
Description	Neutrophil elastase human protein, 0.1 mg
Species	Human
Protein Source	Neutrophils
Concentration	lot specific
Purity	>95% pure by SDS-PAGE
Buffer	Presentation State: Purified State: Lyophilized purified protein containing no preservatives.
Reconstitution	Restore with 50mM Sodium Acetate, pH 5.5 containing 150mM Sodium Chloride.
Preparation	Lyophilized purified protein containing no preservatives.
Protein Description	Human Neutrophil Elastase.
Note	Caution: Prepared from whole blood shown to be nonreactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA licensed tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
Storage	Store the antigen at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: six months from despatch.
Reference Data
RefSeq	NP_001963
Locus ID	1991
Cytogenetics	19p13.3
Synonyms	ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE
Summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]
Protein Families	Protease, Transmembrane
Protein Pathways	Systemic lupus erythematosus

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