IAP4 / BIRC5 (full length) Human Protein
CAT#: AR03007PU-L
IAP4 / BIRC5 (full length) human recombinant protein, 0.5 mg
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CNY 14,920.00
货期*
详询
规格
Cited in 40 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAKG SHMGAPTLPP AWQPFLKDHR ISTFKNWPFL EGCACTPERM AEAGFIHCPT ENEPDLAQCF FCFKELEGWE PDDDPIEEHK KHSSGCAFLS VKKQFEELTL GEFLKLDRER AKNKIAKETN NKKKEFEETA KKVRRAIEQL AAMD
|
Predicted MW | 33 kDa |
Concentration | lot specific |
Purity | > 90% by SDS PAGE |
Buffer | Presentation State: Purified State: Liquid protein, purified by conventional chromatography techniques Buffer System: 20 mM Tris pH 7.5, 0.1M NaCl |
Preparation | Liquid protein, purified by conventional chromatography techniques |
Protein Description | Recombinant human Survivin fused to CaM-tag at N-terminus |
Note | NCBI Accession No: AAH34148 |
Storage | Store at -20 °C. Avoid repeated freezing and thawing. |
Stability | Shelf life: six months from despatch. |
Reference Data | |
RefSeq | NP_001012270 |
Locus ID | 332 |
UniProt ID | O15392 |
Cytogenetics | 17q25.3 |
Synonyms | API4; EPR-1 |
Summary | This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
Protein Families | Druggable Genome, Stem cell - Pluripotency |
Protein Pathways | Colorectal cancer, Pathways in cancer |
Citations (40)
The use of this Proteins has been cited in the following citations: |
---|
Serum SNTF, a Surrogate Marker of Axonal Injury, Is Prognostic for Lasting Brain Dysfunction in Mild TBI Treated in the Emergency Department
,null,
Frontiers in Neurology
,PubMed ID 32322237
[BIRC5]
|
A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts
,null,
Cell Research
,PubMed ID 31270412
[BIRC5]
|
The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis.
,null,
Nature
,PubMed ID 30728500
[BIRC5]
|
Structure-Based Identification of Potent Natural Product Chemotypes as Cannabinoid Receptor 1 Inverse Agonists
,null,
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
,PubMed ID 30322136
[BIRC5]
|
Regenerating islet-derived 1α (REG-1α) protein increases tau phosphorylation in cell and animal models of tauopathies.
,null,
Neurobiology of disease
,PubMed ID 30092268
[BIRC5]
|
Loss of the Cyclin-Dependent Kinase Inhibitor 1 in the Context of Brachyury-Mediated Phenotypic Plasticity Drives Tumor Resistance to Immune Attack
,null,
Frontiers in Oncology
,PubMed ID 29774202
[BIRC5]
|
Radiation resistance of the lung adenocarcinoma is related to the AKT-Onzin-POU5F1 axis.
,null,
Biochemical and biophysical research communications
,PubMed ID 29596836
[BIRC5]
|
A new enzyme-linked immunosorbent assay for neurofilament light in cerebrospinal fluid: analytical validation and clinical evaluation
,null,
Alzheimer's Research & Therapy
,PubMed ID 29370869
[BIRC5]
|
Secondary metabolites isolated from Pinus roxburghii and interpretation of their cannabinoid and opioid binding properties by virtual screening and in vitro studies
,null,
Saudi Pharmaceutical Journal : SPJ
,PubMed ID 29556136
[BIRC5]
|
Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System
,null,
Journal of Virology
,PubMed ID 27489280
[BIRC5]
|
Development of a Δ9-Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability
,null,
Investigative Ophthalmology & Visual Science
,PubMed ID 28399267
[BIRC5]
|
Targeting estrogen receptor signaling with fulvestrant enhances immune and chemotherapy-mediated cytotoxicity of human lung cancer
,null,
Clinical cancer research : an official journal of the American Association for Cancer Research
,PubMed ID 27267852
[BIRC5]
|
Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies
,null,
mAbs
,PubMed ID 27232760
[BIRC5]
|
Transfection of Sertoli cells with androgen receptor alters gene expression without androgen stimulation
,null,
BMC Molecular Biology
,PubMed ID 26715186
[BIRC5]
|
The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival
,null,
Journal of immunology (Baltimore, Md. : 1950)
,PubMed ID 25810396
[BIRC5]
|
Targeting MYCN IRES in MYCN-amplified neuroblastoma with miR-375 inhibits tumor growth and sensitizes tumor cells to radiation
,null,
Molecular Oncology
,PubMed ID 25864587
[BIRC5]
|
Modulation of the Mevalonate Pathway by Akt Regulates Macrophage Survival and Development of Pulmonary Fibrosis *
,null,
The Journal of Biological Chemistry
,PubMed ID 25378391
[BIRC5]
|
MDR1 Transporter Protects Against Paraquat-Induced Toxicity in Human and Mouse Proximal Tubule Cells
,null,
Toxicological Sciences
,PubMed ID 25015657
[BIRC5]
|
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity
,null,
Oncogene
,PubMed ID 24704829
[BIRC5]
|
RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis
,null,
Oncotarget
,PubMed ID 24952599
[BIRC5]
|
Selective Recapitulation of Conserved and Nonconserved Regions of Putative NOXA1 Protein Activation Domain Confers Isoform-specific Inhibition of Nox1 Oxidase and Attenuation of Endothelial Cell Migration *
,null,
The Journal of Biological Chemistry
,PubMed ID 24187133
[BIRC5]
|
Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells.
,null,
Cellular signalling
,PubMed ID 24333325
[BIRC5]
|
Dynamic trafficking of STAT5 depends on an unconventional nuclear localization signal
,null,
Journal of Cell Science
,PubMed ID 23704351
[BIRC5]
|
The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies
,null,
Cell Death & Disease
,PubMed ID 23788039
[BIRC5]
|
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.
,null,
Human molecular genetics
,PubMed ID 23704327
[BIRC5]
|
Identifying Key Juxtamembrane Interactions in Cell Membranes Using AraC-based Transcriptional Reporter Assay (AraTM) *
,null,
The Journal of Biological Chemistry
,PubMed ID 22822084
[BIRC5]
|
Upregulation of the Coagulation Factor VII Gene during Glucose Deprivation Is Mediated by Activating Transcription Factor 4
,null,
PLoS ONE
,PubMed ID 22848420
[BIRC5]
|
Agammaglobulinemia and absent B lineage cells in a patient lacking the p85? subunit of PI3K
,null,
The Journal of Experimental Medicine
,PubMed ID 22351933
[BIRC5]
|
Atrial natriuretic peptide-Fc, ANP-Fc, fusion proteins: semisynthesis, in vitro activity and pharmacokinetics in rats.
,null,
Bioconjugate chemistry
,PubMed ID 22263969
[BIRC5]
|
A fluorescent assay for ceramide synthase activity
,null,
Journal of Lipid Research
,PubMed ID 22661289
[BIRC5]
|
Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling
,null,
Nucleic Acids Research
,PubMed ID 22075993
[BIRC5]
|
Granzyme B-dependent proteolysis acts as a switch to enhance the pro-inflammatory activity of IL-1?
,null,
Molecular cell
,PubMed ID 22017873
[BIRC5]
|
Conserved Molecular Interactions within the HBO1 Acetyltransferase Complexes Regulate Cell Proliferation
,null,
Molecular and Cellular Biology
,PubMed ID 22144582
[BIRC5]
|
Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain
,null,
Journal of neurochemistry
,PubMed ID 21752024
[BIRC5]
|
Regulation of the Incorporation of Tissue Factor into Microparticles by Serine Phosphorylation of the Cytoplasmic Domain of Tissue Factor *
,null,
The Journal of Biological Chemistry
,PubMed ID 21310953
[BIRC5]
|
Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence
,null,
Mechanisms of Ageing and Development
,PubMed ID 21549744
[BIRC5]
|
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells
,null,
The Journal of Clinical Investigation
,PubMed ID 20071775
[BIRC5]
|
Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR
,null,
Protein Science : A Publication of the Protein Society
,PubMed ID 19177347
[BIRC5]
|
cAMP-dependent Protein Kinase A (PKA) Signaling Induces TNFR1 Exosome-like Vesicle Release via Anchoring of PKA Regulatory Subunit RII? to BIG2 *
,null,
,PubMed ID 18625701
[BIRC5]
|
Systematic Identification of Cellular Signals Reactivating Kaposi Sarcoma-Associated Herpesvirus
,null,
PLoS Pathogens
,PubMed ID 17397260
[BIRC5]
|
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