HSP90 Inhibitor Protein

Specifications

Product Data
Predicted MW	558.7
Purity	>98% pure (TLC: 5% Methanol/Methylene Chloride, Rf=0.26).
Buffer	Presentation State: Purified State: Purple solid
Preparation	Purple solid
Protein Description	Red to dark red powder. CAS No: 75747-14-7 Formula: C31H43N3O8
Storage	Upon receipt, store at -20°C.
Stability	Shelf life: one year from despatch.
Reference Data
Summary	Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17- AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5).

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