Thiopurine methyltransferase (TPMT) (1-245) Human Protein
CAT#: AR09087PU-L
Thiopurine methyltransferase (TPMT) (1-245) human recombinant protein, 0.5 mg
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CNY 17,930.00
货期*
详询
规格
Cited in 1 publication. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK
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Predicted MW | 28 kDa |
Concentration | lot specific |
Purity | ≥95 pure by SDS-PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl, 8.0, 0.2 mM PMSF, 2 mM EDTA |
Preparation | Liquid purified protein |
Protein Description | Recombinant Human TPMT was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_000358 |
Locus ID | 7172 |
UniProt ID | P51580, A0A024QZW0 |
Cytogenetics | 6p22.3 |
Synonyms | TPMTD |
Summary | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014] |
Protein Families | Druggable Genome |
Protein Pathways | Drug metabolism - other enzymes |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines
,null,
PLoS ONE
,PubMed ID 28406961
[TPMT]
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