GRB2 / ASH (1-217, His-tag) Human Protein
CAT#: AR09166PU-L
GRB2 / ASH (1-217, His-tag) human recombinant protein, 0.5 mg
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CNY 14,920.00
货期*
详询
规格
Cited in 5 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV
|
Tag | His-tag |
Concentration | lot specific |
Purity | >95% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl (pH 8.0) buffer containing 30% glycerol |
Preparation | Liquid purified protein |
Protein Description | Recombinant human GRB2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_002077 |
Locus ID | 2885 |
UniProt ID | P62993, B0LPF3 |
Cytogenetics | 17q25.1 |
Synonyms | ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2 |
Summary | The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Protein Pathways | Acute myeloid leukemia, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Dorso-ventral axis formation, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Prostate cancer, Renal cell carcinoma, T cell receptor signaling pathway |
Citations (5)
The use of this Proteins has been cited in the following citations: |
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LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway.
,null,
Experimental cell research
,PubMed ID 32841643
[GRB2]
|
Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers
,null,
Biochemistry
,PubMed ID 24697349
[GRB2]
|
Cellular Localization and Characterization of Cytosolic Binding Partners for Gla Domain-containing Proteins PRRG4 and PRRG2 *
,null,
The Journal of Biological Chemistry
,PubMed ID 23873930
[GRB2]
|
Profiling Epidermal Growth Factor Receptor and Heregulin Receptor 3 Heteromerization Using Receptor Tyrosine Kinase Heteromer Investigation Technology
,null,
PLoS ONE
,PubMed ID 23700486
[GRB2]
|
Phosphatidic Acid Is a Leukocyte Chemoattractant That Acts through S6 Kinase Signaling *
,null,
The Journal of Biological Chemistry
,PubMed ID 20304930
[GRB2]
|
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