TCL1A / TCL1 (1-114) Human Protein
CAT#: AR09274PU-L
TCL1A / TCL1 (1-114) human recombinant protein, 0.5 mg
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CNY 12,210.00
货期*
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规格
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD
|
Predicted MW | 13.4 kDa |
Concentration | lot specific |
Purity | >90% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: Liquid in. Phosphate-Buffered Saline (pH 7.4) |
Preparation | Liquid purified protein |
Protein Description | Recombinant TCL1A protein was expressed in E.coli and purified by using conventional chromatography techniques. |
Note | (Real molecular weight on SDS-PAGE will be shift up). |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001092195 |
Locus ID | 8115 |
UniProt ID | P56279, A0A024R6G5 |
Cytogenetics | 14q32.13 |
Synonyms | TCL1 |
Summary | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] |
Protein Families | Druggable Genome |
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