SKP1 / OCP2 (1-160) Human Protein
CAT#: AR09313PU-L
SKP1 / OCP2 (1-160) human recombinant protein, 0.5 mg
Need it in bulk or customized? Get a free quote |
CNY 13,720.00
货期*
详询
规格
Cited in 2 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVGSTQFCL
|
Concentration | lot specific |
Purity | >90% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 50 mM NaCl, 10% glycerol |
Preparation | Liquid purified protein |
Protein Description | Recombinant human SKP1 protein was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_008861 |
Locus ID | 6500 |
UniProt ID | P63208 |
Cytogenetics | 5q31.1 |
Synonyms | EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L |
Summary | This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Protein Pathways | Cell cycle, Oocyte meiosis, TGF-beta signaling pathway, Ubiquitin mediated proteolysis, Wnt signaling pathway |
Citations (2)
The use of this Proteins has been cited in the following citations: |
---|
FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy
,null,
Genome Biology
,PubMed ID 26753747
[SKP1]
|
The F-box Protein FBXO44 Mediates BRCA1 Ubiquitination and Degradation *
,null,
The Journal of Biological Chemistry
,PubMed ID 23086937
[SKP1]
|
Documents
FAQs |
SDS |
Customer
Reviews
Loading...