PCMT1 / PIMT (1-227, His-tag) Human Protein
CAT#: AR09515PU-L
PCMT1 / PIMT (1-227, His-tag) human recombinant protein, 0.5 mg
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CNY 13,720.00
货期*
详询
规格
Cited in 4 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAWK SGGASHSELI HNLRKNGIIK TDKVFEVMLA TDRSHYAKCN PYMDSPQSIG FQATISAPHM HAYALELLFD QLHEGAKALD VGSGSGILTA CFARMVGCTG KVIGIDHIKE LVDDSINNVR KDDPTLLSSG RVQLVVGDGR MGYAEEAPYD AIHVGAAAPV VPQALIDQLK PGGRLILPVG PAGGNQMLEQ YDKLQDGSIK MKPLMGVIYV PLTDKEKQWS RWK
|
Tag | His-tag |
Predicted MW | 28.8 kDa |
Concentration | lot specific |
Purity | >95% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1 M NaCl |
Preparation | Liquid purified protein |
Protein Description | Recombinant human PCMT1 protien, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001238978 |
Locus ID | 5110 |
UniProt ID | P22061, H7BY58 |
Cytogenetics | 6q25.1 |
Synonyms | PIMT |
Summary | This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
Protein Families | Druggable Genome |
Citations (4)
The use of this Proteins has been cited in the following citations: |
---|
The Protein L-Isoaspartyl (D-Aspartyl) Methyltransferase Regulates Glial-to-Mesenchymal Transition and Migration Induced by TGF-β1 in Human U-87 MG Glioma Cells
,null,
International Journal of Molecular Sciences
,PubMed ID 35628507
[PCMT1]
|
The enzyme L-isoaspartyl (D-aspartyl) methyltransferase is required for VEGF-dependent endothelial cell migration and tubulogenesis.
,null,
Molecular and cellular biochemistry
,PubMed ID 26738492
[PCMT1]
|
The protein l-isoaspartyl (d-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells.
,null,
Neuroscience
,PubMed ID 25800307
[PCMT1]
|
The MicroRNA 15a/16-1 Cluster Down-regulates Protein Repair Isoaspartyl Methyltransferase in Hepatoma Cells
,null,
The Journal of Biological Chemistry
,PubMed ID 22033921
[PCMT1]
|
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