SAE1 / AOS1 (1-346, T7-tag) Human Protein
CAT#: AR09547PU-L
SAE1 / AOS1 (1-346, T7-tag) human recombinant protein, 0.25 mg
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CNY 14,920.00
货期*
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规格
Cited in 2 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MHHHHHHMAS MTGGQQMGRD LYDDDDKDRW GSMVEKEEAG GGISEEEAAQ YDRQIRLWGL EAQKRLRASR VLLVGLKGLG AEIAKNLILA GVKGLTMLDH EQVTPEDPGA QFLIRTGSVG RNRAEASLER AQNLNPMVDV KVDTEDIEKK PESFFTQFDA VCLTCCSRDV IVKVDQICHK NSIKFFTGDV FGYHGYTFAN LGEHEFVEEK TKVAKVSQGV EDGPDTKRAK LDSSETTMVK KKVVFCPVKE ALEVDWSSEK AKAALKRTTS DYFLLQVLLK FRTDKGRDPS SDTYEEDSEL LLQIRNDVLD SLGISPDLLP EDFVRYCFSE MAPVCAVVGG ILAQEIVKAL SQRDPPHNNF FFFDGMKGNG IVECLGPK
|
Tag | T7-tag |
Predicted MW | 42.2 kDa |
Concentration | lot specific |
Purity | >90% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 10% glycerol |
Preparation | Liquid purified protein |
Protein Description | Recombinant human SAE1 protein, fused to His-T7-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001139185 |
Locus ID | 10055 |
UniProt ID | Q9UBE0 |
Cytogenetics | 19q13.32 |
Synonyms | AOS1; HSPC140; SUA1; UBLE1A |
Summary | Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
Protein Pathways | Ubiquitin mediated proteolysis |
Citations (2)
The use of this Proteins has been cited in the following citations: |
---|
Clinical characteristics of anti-SAE antibodies in Chinese patients with dermatomyositis in comparison with different patient cohorts
,null,
Scientific Reports
,PubMed ID 28298642
[SAE1]
|
Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
,null,
Nature Communications
,PubMed ID 26068603
[SAE1]
|
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