HIF1A / HIF1 alpha (576-785, His-tag) Human Protein
CAT#: AR09585PU-L
HIF1A / HIF1 alpha (576-785, His-tag) human recombinant protein, 0.25 mg
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CNY 14,920.00
货期*
详询
规格
Cited in 4 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MSFDQLSPLE SSSASPESAS PQSTVTVFQQ TQIQEPTANA TTTTATTDEL KTVTKDRMED IKILIASPSP THIHKETTSA TSSPYRDTQS RTASPNRAGK GVIEQTEKSH PRSPNVLSVA LSQRTTVPEE ELNPKILALQ NAQRKRKMEH DGSLFQAVGI GTLLQQPDDH AATTSLSWKR VKGCKSSEQN GMEQKTIILI PSDLACRLLG Q
|
Tag | His-tag |
Predicted MW | 25.1 kDa |
Concentration | lot specific |
Purity | >85% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 1 mM DTT, 10% glycerol |
Preparation | Liquid purified protein |
Protein Description | Recombinant human HIF1A (576-785) protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001230013 |
Locus ID | 3091 |
UniProt ID | Q16665 |
Cytogenetics | 14q23.2 |
Synonyms | bHLHe78; HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8 |
Summary | This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] |
Protein Families | Transcription Factors |
Protein Pathways | mTOR signaling pathway, Pathways in cancer, Renal cell carcinoma |
Citations (4)
The use of this Proteins has been cited in the following citations: |
---|
A Renal Cell Carcinoma with Biallelic Somatic TSC2 Mutation: Clinical Study and Literature Review.
,null,
Urology
,PubMed ID 31454656
[HIF1A]
|
HIF Inactivation of p53 in Ovarian Cancer Can Be Reversed by Topotecan, Restoring Cisplatin and Paclitaxel Sensitivity.
,null,
Molecular cancer research : MCR
,PubMed ID 31088908
[HIF1A]
|
Variations of CITED2 Are Associated with Congenital Heart Disease (CHD) in Chinese Population
,null,
PLoS ONE
,PubMed ID 24848765
[HIF1A]
|
Hypoxia-induced invadopodia formation: a role for ?-PIX
,null,
Open Biology
,PubMed ID 23740575
[HIF1A]
|
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