Gremlin-1 / GREM1 Mouse Protein

Specifications

Product Data
Species	Mouse
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MKKKGSQGAI PPPDKAQHND SEQTQSPPQP GSRTRGRGQG RGTAMPGEEV LESSQEALHV TERKYLKRDW CKTQPLKQTI HEEGCNSRTI INRFCYGQCN SFYIPRHIRK EEGSFQSCSF CKPKKFTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
Predicted MW	28 kDa
Purity	>95% by SDS-PAGE & Silver staining
Buffer	Presentation State: Purified State: Lyophilized protein Buffer System: 50 mM acetic acid, without stabilizers
Preparation	Lyophilized protein
Protein Description	Recombinant mouse Gremlin-1 / GREM1, aa. 160
Note	Protein RefSeq: NP_035954.1 mRNA RefSeq: NM_011824
Storage	The lyophilized protein is stable at room temperature for up to 1 week or at -20 °C for longer. Following reconstitution store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Endotoxin	< 0.1 ng per μg of Grem1
Reference Data
RefSeq	NP_035954
Locus ID	23892
UniProt ID	O70326, Q3TNY7
Cytogenetics	2 57.43 cM
Synonyms	Cktsf1b1; Drm; Grem; ld
Summary	Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop (PubMed:12808456, PubMed:15201225). Down-regulates the BMP4 signaling in a dose-dependent manner (PubMed:15133038). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (By similarity).[UniProtKB/Swiss-Prot Function]

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