CD70 Human Protein

Specifications

Product Data
Species	Human
Expression Host	CHO
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) HHHHHHHHPS PGGSGGQRFA QAQQQLPLES LGWDVAELQL NHTGPQQDPR LYWQGGPALG RSFLHGPELD KGQLRIHRDG IYMVHIQVTL AICSSTTASR HHPTTLAVGI CSPASRSISL LRLSFHQGCT IASQRLTPLA RGDTLCTNLT GTLLPSRNTD ETFFGVQWVR P
Predicted MW	18.8 kDa
Purity	>95% by SDS-PAGE gel and HPLC analyses
Buffer	Presentation State: Purified State: Lyophylized purified protein
Preparation	Lyophylized purified protein
Protein Description	Recombinant Human sCD27L contains the extracellular domain plus an N-terminal His-Tag. The calculated molecular weight of Recombinant Human sCD27L is 18.8 kDa.
Note	Centrifuge vial before opening.
Storage	Store the lyophilized protein at -20°C. Following reconstitution product is stable for 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: One year from despatch.
Bioactivity	Biological: Determined by its ability to stimulate human IL-8 production by Human PBMC using a concentration range of 10.0-25.0 ng/ml. Note: Results may vary with PBMC donors.
Endotoxin	< 0.1 ng per μg (1EU/μg)
Reference Data
RefSeq	NP_001243
Locus ID	970
UniProt ID	P32970
Cytogenetics	19p13.3
Synonyms	CD27 ligand, CD27L, CD27LG, TNFSF7
Summary	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
Protein Families	ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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