CD22 Human Protein
CAT#: AR31157PU-N
CD22 human recombinant protein, 20 µg
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CNY 5,900.00
货期*
7周
规格
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Specifications
Product Data | |
Species | Human |
Expression Host | CHO |
Expression cDNA Clone or AA Sequence |
SKWVFEHPET LYAWEGACVW IPCTYRALDG DLESFILFHN PEYNKN TSKF DGTRLYESTK DGKVPSEQKR VQFLGDKNKN CTLSIHPVHL N DSGQLGLRM ESKTEKWMER IHLNVSERPF PPHIQLPPEI QESQEVT LTC LLNFSCYGYP IQLQWLLEGV PMRQAAVTST SLTIKSVFTR SE LKFSPQWS HHGKIVTCQL QDADGKFLSN DTVQLNVKHT PKLEIKVT PS DAIVREGDSV TMTCEVSSSN PEYTTVSWLK DGTSLKKQNT FTL NLREVTK DQSGKYCCQV SNDVGPGRSE EVFLQVQYAP EPSTVQILH S PAVEGSQVEF LCMSLANPLP TNYTWYHNGK EMQGRTEEKV HIPK ILPWHA GTYSCVAENI LGTGQRGPGA ELDVQYPPKK VTTVIQNPMP IREGDTVTLS CNYNSSNPSV TRYEWKPHGA WEEPSLGVLK IQNVG WDNTT IACARCNSWC SWASPVALNV QYAPRDVRVR KIKPLSEIHS GNSVSLQCDF SSSHPKEVQF FWEKNGRLLG KESQLNFDSI SPEDAG SYSC WVNNSIGQTA SKAWTLEVLY APRRLRVSMS PGDQVMEGKS A TLTCESDAN PPVSHYTWFD WNNQSLPHHS QKLRLEPVKV QHSGAYW CQG TNSVGKGRSP LSTLTVYYSP ETIGRR
|
Predicted MW | 75 kDa |
Purity | >98% by SDS-PAGE & HPLC analysis |
Buffer | Presentation State: Purified State: Lyophilized purified protein Buffer System: PBS without stabilizers |
Preparation | Lyophilized purified protein |
Protein Description | Recombinant Human CD22 is a soluble 75.0 kDa (666 amino acid residues) protein which corresponds to the extracellular domain of CD22. |
Note | Centrifuge vials before opening! |
Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Bioactivity | Biological: Determined by its ability to inhibit the proliferation of Raji cells. The expected ED50 for this effect is 10-17 μg/ml. |
Reference Data | |
Locus ID | 79978 |
Cytogenetics | 19q13.13 |
Synonyms | SIGLEC-2; SIGLEC2 |
Summary | CD22 is a 135 kDa B-cell restricted sialoglycoprotein that binds to oligosaccharides containing 2-6-linked sialic acid residues. It is present in the cytoplasm of nearly all B-lineage cells and is also expressed on the surface of B-cells during advance stages of differentiation. Although the exact physiological function of CD22 is unclear, it appears to play a role in B-cell activation and to act as an adhesion molecule. The potential therapeutic use of CD22 and anti-CD22 may be useful in diagnostic and/or treatment of leukemia, lymphoma, non-Hodgkin's lymphoma and certain autoimmune conditions. (Cesano A. and Gayko U. Semin. Oncol. Apr. 2003 (2): 253-257). |
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