Glutathione peroxidase 1 / GPX1 (1-203, His-tag) Human Protein
CAT#: AR50098PU-N
Glutathione peroxidase 1 / GPX1 (1-203, His-tag) human recombinant protein, 0.5 mg
Size: 100 ug
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CNY 14,920.00
货期*
详询
规格
Cited in 4 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLCG TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP SCA
|
Tag | His-tag |
Predicted MW | 24.2 kDa |
Concentration | lot specific |
Purity | >90% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 2 mM DTT, 30% glycerol, 100 mM NaCl |
Preparation | Liquid purified protein |
Protein Description | Recombinant human GPX1(U49C) protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_000572 |
Locus ID | 2876 |
UniProt ID | P07203, Q7L4Q3 |
Cytogenetics | 3p21.31 |
Synonyms | GSHPx-1, Cellular glutathione peroxidase |
Summary | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017] |
Protein Families | Druggable Genome |
Protein Pathways | Amyotrophic lateral sclerosis (ALS), Arachidonic acid metabolism, Glutathione metabolism, Huntington's disease |
Citations (4)
The use of this Proteins has been cited in the following citations: |
---|
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
,null,
Nature immunology
,PubMed ID 33398183
[GPX1]
|
Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells
,null,
Cardiovascular Diabetology
,PubMed ID 27137793
[GPX1]
|
The glutathione mimic ebselen inhibits oxidative stress but not endoplasmic reticulum stress in endothelial cells.
,null,
Life sciences
,PubMed ID 26006036
[GPX1]
|
Reactive oxygen species (ROS) by p66Shc longevity protein mediate non-genomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells
,null,
Free radical biology & medicine
,PubMed ID 22561705
[GPX1]
|
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