Beclin-1 (1-450, His-tag) Human Protein
CAT#: AR50640PU-N
Beclin-1 (1-450, His-tag) human recombinant protein, 0.1 mg
Size: 20 ug
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CNY 14,920.00
货期*
详询
规格
Cited in 6 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN SEEQWTKALK FMLTNLKWGL AWVSSQFYNK
|
Tag | His-tag |
Predicted MW | 54.1 kDa |
Concentration | lot specific |
Purity | >85% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.5) containing 0.1M NaCl, 10% glycerol, 1 mM DTT |
Preparation | Liquid purified protein |
Protein Description | Recombinant human BECN1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional column chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001300927 |
Locus ID | 8678 |
UniProt ID | Q14457, A0A024R1X5 |
Cytogenetics | 17q21.31 |
Synonyms | ATG6; beclin1; VPS30 |
Summary | This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
Protein Families | Druggable Genome |
Protein Pathways | Regulation of autophagy |
Citations (6)
The use of this Proteins has been cited in the following citations: |
---|
NOS2 inhibitor 1400W Induces Autophagic Flux and Influences Extracellular Vesicle Profile in Human Glioblastoma U87MG Cell Line
,null,
International Journal of Molecular Sciences
,PubMed ID 31226744
[BECN1]
|
Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion.
,null,
Nutrition research (New York, N.Y.)
,PubMed ID 31103857
[BECN1]
|
Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation
,null,
The Journal of Clinical Investigation
,PubMed ID 25642769
[BECN1]
|
Autophagic program is regulated by miR-325
,null,
Cell Death and Differentiation
,PubMed ID 24531537
[BECN1]
|
Inhibition of mTOR Kinase by AZD8055 Can Antagonize Chemotherapy-induced Cell Death through Autophagy Induction and Down-regulation of p62/Sequestosome 1 *
,null,
The Journal of Biological Chemistry
,PubMed ID 21949121
[BECN1]
|
Targeting the Autophagy Pathway Using Ectopic Expression of Beclin 1 in Combination with Rapamycin in Drug-Resistant v-Ha-ras-Transformed NIH 3T3 Cells
,null,
Molecules and Cells
,PubMed ID 21350938
[BECN1]
|
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