SOCS3 / CIS3 (1-225, His-tag) Human Protein
CAT#: AR51409PU-N
SOCS3 / CIS3 (1-225, His-tag) human recombinant protein, 0.25 mg
Size: 50 ug
Need it in bulk or customized? Get a free quote |
CNY 17,930.00
货期*
详询
规格
Cited in 3 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMVT HSKFPAAGMS RPLDTSLRLK TFSSKSEYQL VVNAVRKLQE SGFYWSAVTG GEANLLLSAE PAGTFLIRDS SDQRHFFTLS VKTQSGTKNL RIQCEGGSFS LQSDPRSTQP VPRFDCVLKL VHHYMPPPGA PSFPSPPTEP SSEVPEQPSA QPLPGSPPRR AYYIYSGGEK IPLVLSRPLS SNVATLQHLC RKTVNGHLDS YEKVTQLPGP IREFLDQYDA PL
|
Tag | His-tag |
Predicted MW | 29 kDa |
Concentration | lot specific |
Purity | >90% by SDS - PAGE |
Buffer | Presentation State: This purified protein is available in a denatured form, making it less suitable for functional studies. Denatured proteins are better suited for applications like Western Blot (WB) or imaging assays. State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol |
Preparation | Liquid purified protein |
Protein Description | Recombinant human SOCS3 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_003946 |
Locus ID | 9021 |
UniProt ID | O14543, Q6FI39 |
Cytogenetics | 17q25.3 |
Synonyms | SOCS-3, CIS-3, SSI3, SSI-3 |
Summary | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Protein Pathways | Adipocytokine signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus, Ubiquitin mediated proteolysis |
Citations (3)
The use of this Proteins has been cited in the following citations: |
---|
Knockdown of miR-92a suppresses the stemness of colorectal cancer cells via mediating SOCS3
,null,
Bioengineered
,PubMed ID 35184640
[SOCS3]
|
Human TH9 differentiation is dependent on signal transducer and activator of transcription (STAT) 3 to restrain STAT1-mediated inhibition.
,null,
The Journal of allergy and clinical immunology
,PubMed ID 30030006
[SOCS3]
|
PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients
,null,
The Journal of Experimental Medicine
,PubMed ID 28710273
[SOCS3]
|
Documents
FAQs |
SDS |
Customer
Reviews
Loading...