SERPINB4 / SCCA2 (1-390, His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGSSHHHHHH SSGLVPRGSH MGSMNSLSEA NTKFMFDLFQ QFRKSKENNI FYSPISITSA LGMVLLGAKD NTAQQISKVL HFDQVTENTT EKAATYHVDR SGNVHHQFQK LLTEFNKSTD AYELKIANKL FGEKTYQFLQ EYLDAIKKFY QTSVESTDFA NAPEESRKKI NSWVESQTNE KIKNLFPDGT IGNDTTLVLV NAIYFKGQWE NKFKKENTKE EKFWPNKNTY KSVQMMRQYN SFNFALLEDV QAKVLEIPYK GKDLSMIVLL PNEIDGLQKL EEKLTAEKLM EWTSLQNMRE TCVDLHLPRF KMEESYDLKD TLRTMGMVNI FNGDADLSGM TWSHGLSVSK VLHKAFVEVT EEGVEAAAAT AVVVVELSSP STNEEFCCNH PFLFFIRQNK TNSILFYGRF SSP
Tag	His-tag
Predicted MW	47.2 kDa
Concentration	lot specific
Purity	>90% by SDS - PAGE
Buffer	Presentation State: Purified State: Liquid purified protein Buffer System: Liquid, In Phosphate buffered saline (pH 7.4) containing 10% glycerol, 1 mM DTT
Preparation	Liquid purified protein
Protein Description	Recombinant Human SERPINB4, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_002965
Locus ID	6318
UniProt ID	P48594
Cytogenetics	18q21.33
Synonyms	LEUPIN; PI11; SCCA-2; SCCA1; SCCA2
Summary	The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
Protein Families	Druggable Genome, Secreted Protein

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