Interleukin-6 / IL6 (30-212) Human Protein
CAT#: AR52011PU-N
Interleukin-6 / IL6 (30-212) human protein, 20 µg
Size: 5 ug
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CNY 8,900.00
货期*
详询
规格
Cited in 5 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
|
Predicted MW | 20.9 kDa |
Concentration | lot specific |
Purity | >95% by SDS – PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: Phosphate buffered saline (pH 7.4). |
Preparation | Liquid purified protein |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Bioactivity | Specific: Measured in a cell proliferation assay using TF-1 human erythroleukemic cell. The ED50 for this effects 0.2 - 0.8 ng/ml. |
Endotoxin | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Reference Data | |
RefSeq | NP_000591 |
Locus ID | 3569 |
UniProt ID | P05231, Q75MH2, B4DVM1 |
Cytogenetics | 7p15.3 |
Synonyms | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 |
Summary | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway |
Citations (5)
The use of this Proteins has been cited in the following citations: |
---|
Upregulation of CBP by PLY can cause permeability of blood-brain barrier to increase meningitis.
,null,
Journal of biochemical and molecular toxicology
,PubMed ID 30980515
[IL6]
|
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression
,null,
Oncogene
,PubMed ID 28288142
[IL6]
|
Regorafenib diminishes the expression and secretion of angiogenesis and metastasis associated proteins and inhibits cell invasion via NF-κB inactivation in SK-Hep1 cells
,null,
Oncology Letters
,PubMed ID 28693192
[IL6]
|
MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury
,null,
BioMed Research International
,PubMed ID 27057544
[IL6]
|
Role of MMP-2 in the Regulation of IL-6/Stat3 Survival Signaling via Interaction With ?5?1 Integrin in glioma
,null,
Oncogene
,PubMed ID 22349830
[IL6]
|
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