PRAME / MAPE Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ LSVLSLSGVM LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP SLSHCSQLTT LSFYGNSISI
Predicted MW	10.7 kDa
Purity	>98% by SDS-PAGE and Silver staining
Buffer	Presentation State: Purified State: Lyophilized protein Buffer System: 10 mM Tris, 25 mM NaP, pH 7.4 Stabilizer: None
Preparation	Lyophilized protein
Applications	Positive control for Western blot analysis. Standard for ELISA.
Protein Description	Recombinant human PRAME fragment corresponding to amino acid sequence Met321 to Ile420.
Note	mRNA RefSeq: NM_006115.3
Storage	Prior to reconstitution store desiccated at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001278644
Locus ID	23532
UniProt ID	P78395, A0A024R1E6
Cytogenetics	22q11.22
Synonyms	CT130; MAPE; OIP-4; OIP4
Summary	This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

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