HIV-2 (390-702) Protein

Specifications

Product Data
Expression Host	E. coli
Concentration	lot specific
Buffer	Presentation State: Purified State: Liquid purified fraction (>95% pure by SDS-PAGE, Bradford Method) Buffer System: 0.01M Na2CO3, 0.01M Na3EDTA, 0.014M beta-Mercaptoethanol and 0.05% Tween 20 Preservative: None
Preparation	Liquid purified fraction (>95% pure by SDS-PAGE, Bradford Method)
Applications	ELISA. Western blot: 1/1000. Colloidal Gold and Latex Beads.
Protein Description	HIV-2 env antigen (recombinant) a.a 390 to a.a 702 of the HIV-2 env region, 34kDa Beta-galactosidase (114 kDa) fused at the N-terminus. Reacts strongly with Human HIV positive serum.
Storage	Store undiluted at 2-8°C for 2 months or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
Synonyms	HIV2, Human immunodeficiency virus type 2
Summary	HIV2 infections at present, are predominantly found in west Africa where it is the dominant form of HIV. Both HIV1 and HIV2 have the same modes of transmission and are associated with similar opportunistic infections and AIDS. In persons infected with HIV2, immunodeficiency seems to develop more slowly and to be milder, but as the disease advances, HIV2 infectiousness seems to increase. Little is known about the best approach to the clinical treatment and care of patients infected with HIV2. Some drugs used to treat HIV1 are ineffective. HIV1 and HIV2 have similar gag (viral core) and pol (polymerase) regions, they have relatively dissimilar env (envelope) regions. Owing to this lack of homology in the envelope region, there is little serologic cross-reactivity of the antibodies directed against the envelope antigens of both HIV1 and HIV2.
Protein Families	ELISA. Western blot: 1/1000. Colloidal Gold and Latex Beads.

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