BMP2 / BMP2A Human Protein
CAT#: DA3502X
BMP2 / BMP2A human recombinant protein, 25 µg
Need it in bulk or customized? Get a free quote |
CNY 8,100.00
货期*
7周
规格
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Predicted MW | 26 kDa |
Purity | >95% pure by SDS-PAGE and visualised by silver stain |
Buffer | Presentation State: Purified State: Lyophilized purified Ig fraction Buffer System: 50 mM Acetic Acid Stabilizer: None |
Preparation | Lyophilized purified Ig fraction |
Protein Description | Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein. BMP-2 lacks the natural N-terminus which results in a 15-20 fold increase of specific activity. The amino acid sequence of recombinant Human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. |
Storage | Lyophilized samples are stable for 6 months from despatch at -20°C to -70°C. Reconstituted BMP-2 should be stored in working aliquots at -20°C. Avoid repeated freezing and thawing. |
Bioactivity | Biological: Measured by the ability of BMP-2 to induce Alkaline Phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 0.3-0.8 µg/ml. Specific: 2.5 x 103 units/mg |
Endotoxin | < 0.1 ng per µg of BMP-2 |
Reference Data | |
RefSeq | NP_001191 |
Locus ID | 650 |
UniProt ID | P12643, C8C060 |
Cytogenetics | 20p12.3 |
Synonyms | BDA2; BMP2A; SSFSC; SSFSC1 |
Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016] |
Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane |
Protein Pathways | Acute myeloid leukemia, Basal cell carcinoma, Cytokine-cytokine receptor interaction, Endocytosis, Hedgehog signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, TGF-beta signaling pathway |
Documents
FAQs |
SDS |
Customer
Reviews
Loading...