VEGFR-3 / Flt-4 (His-tagged) Human Protein

Specifications

Product Data
Species	Human
Expression Host	Insect
Tag	His-tag
Predicted MW	120 kDa
Purity	>90% by SDS-PAGE and visualised by silver stain
Buffer	Presentation State: Purified State: Lyophilized without buffer and stabilizer.
Preparation	Lyophilized without buffer and stabilizer.
Protein Description	The recombinant mature sVEGFR-3/FLT-4 is a glycosylated monomeric protein with a mass of approximately 120 kDa. The soluble receptor protein consists of all 7 extracellular domains (Met1-Glu774).
Note	Centrifuge vials before opening!
Storage	Prior to and following reconstitution store the antibody at -20°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Bioactivity	Biological: Measured by its ability to bind recombinant rat VEGF-C in a functional solid phase binding assay. Immobilised recombinant human sVEGFR-3/FLT-4 at 5 µg/ml can bind recombinant rat VEGF-C in a linear range of 8-500 ng/ml.
Endotoxin	< 0.1 ng per µg of sVEGFR-3
Reference Data
RefSeq	NP_001341918
Locus ID	2324
Cytogenetics	5q35.3
Synonyms	VEGFR3, FLT4, VEGF Receptor 3
Summary	This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Focal adhesion

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