VHL (1-154, His-tag) Human Protein
CAT#: SA6057X
VHL (1-154, His-tag) human protein, 0.5 mg
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CNY 12,210.00
货期*
详询
规格
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP
|
Tag | His-tag |
Predicted MW | 19 kDa |
Concentration | lot specific |
Purity | >95% > 95% by SDS PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: PBS, 1 mM DTT, 2 mM EDTAI, pH 7.4 |
Preparation | Liquid purified protein |
Protein Description | VHL beta-domain (1-154 aa), fused to HIs-tag, was overexpressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_000542 |
Locus ID | 7428 |
UniProt ID | P40337, A0A024R2F2 |
Cytogenetics | 3p25.3 |
Synonyms | HRCA1; pVHL; RCA1; VHL1 |
Summary | Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis |
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