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Cathepsin L (CTSL) (NM_145918) Human Recombinant Protein
CAT＃: TP323541
Recombinant protein of human cathepsin L1 (CTSL1), transcript variant 2, 20 µg
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
>RC223541 protein sequence
Red=Cloning site Green=Tags(s) MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNVKMIELHNQEYREGK HSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWA FSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEES CKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLV VGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Predicted MW | 35.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_666023 |
| Locus ID | 1514 |
| UniProt ID | P07711 |
| Refseq Size | 1587 |
| Cytogenetics | 9q21.33 |
| Refseq ORF | 999 |
| Synonyms | CATL; CTSL1; MEP |
| Summary | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020] |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Antigen processing and presentation, Lysosome |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC400711 | CTSL HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC407805 | CTSL HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY400711 | Transient overexpression lysate of cathepsin L1 (CTSL1), transcript variant 1 |
CNY 3,080.00 |
|
| LY407805 | Transient overexpression lysate of cathepsin L1 (CTSL1), transcript variant 2 |
CNY 3,080.00 |
|
| PH303143 | CTSL1 MS Standard C13 and N15-labeled recombinant protein (NP_001903) |
CNY 19,520.00 |
|
| PH323541 | CTSL1 MS Standard C13 and N15-labeled recombinant protein (NP_666023) |
CNY 19,520.00 |
|
| TP303143 | Recombinant protein of human cathepsin L1 (CTSL1), transcript variant 1, 20 µg |
CNY 2,900.00 |
|
| TP720657 | Purified recombinant protein of Human cathepsin L1 (CTSL1), transcript variant 1 |
CNY 3,140.00 |
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