Ttll12 (NM_183017) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR209682 protein sequence Red=Cloning site Green=Tags(s) MEIQSGPQPGSPGRAERLNARLLDEFVSLHGPTLRASGVPERLWGRLLHKLEHEVFDAGEMFGIKQVEEV EEAEDEAAREAQRKQPNPGGELCYKVIVTSESGVRADDPNSIFLIDHAWTCRVEHARKQLQQVPGLLHRM ANLMGIEFHGEVPSPEVVALVLEEMWKFNQTYQLAHGTAEEKVPVWYIMDEFGSRIQHSDMPSFATAPFF YMPQQVAYTLLWPLRDLDTGEEVTRDFAYGEADPLIRKCMLLPWAPADMLDLSFSTPEPPAKYYQAILEE NKEKLPLAISPVARPQGHVFRVHCDVQQVLGHLTHPRFTFTDSEADADIFFHFSHFKDYMKLSQESPQVL LNQFPCENLLTVKDCLASIARRAGGPEGPPWLPRTFNLRTELPQFVSYFQHRERRGEDNHWICKPWNLAR SLDTHVTNNLHSIIRHRESTPKVVSKYIESPVLFLREDVGNVKFDIRYIVLLRSVRPLRLFAYDVFWLRF SNRPFALDDLDDYEKHFTVMNYDPDVVLKQVHYNEFIPQFEKQYPEFPWSDVQAEIFKAFTELFQVACAK PPPMGLCDYPSSRAMYAIDLMLNWDNHPDGKRVMQPQILEVNFNPDCERACRYHPSFFNDVFSTLFLDET DNCHVTRII TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	74 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_898838
Locus ID	223723
UniProt ID	Q3UDE2
Refseq Size	3770
Cytogenetics	15 E1
Refseq ORF	1920
Synonyms	BC055368; D430005B17
Summary	Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.[UniProtKB/Swiss-Prot Function]

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