Taok2 (NM_001163775) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR215627 representing NM_001163775 Red=Cloning site Green=Tags(s) MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKW QDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLA YLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWS LGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF VLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEELTPCSQEAEPYTHRAGT LTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEHTVTSH SSIIHRLPGSDNLYDDPYQPEMTPGPLQPPAAPPTSTSSSARRRAYCRNRDHFATIRTASLVSRQIQEHE QDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTEAEKLARRHQAIGEKE ARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQC QAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELR QLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQLPMGLPATGALGPL STGTPSEEQPCSSGQEAILDQRMLGEEEEAVPERRILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLA NEEDWDISEEMKEIRVPSLASQERNIIGQEEAAAWSLWEKEGGNLVDVEFKLGWVQGPVLTPVPEEEEEE EEEGGAPIGTHRDPGDGCPSPDIPPEPPPSHLRQYPTSQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLL LPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPGLFLLLAQGTALLAVLSLSWRRGLMGVPL GLGAAWLLAWPSLALPLAAMAAGGKWVRQQGPQMRRGISRLWLRILLRLSPMVFRALQGCGAVGDRGLFA LYPKTNKNGFRSRLPVPWPRQGNPRTTQHPLAQLTRVWAVCKGWNWRLARASHRLASCLPPWAVHILASW GLLKGERPSRIPRLLPRSQRRLGLSASRQLPPGTVAGRRSQTRRTLPPWR TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	139.3 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_001157247
Locus ID	381921
UniProt ID	Q6ZQ29
Refseq Size	5270
Cytogenetics	7 F3
Refseq ORF	3720
Synonyms	1110033K02Rik; B230344N16; MAP3K17; mKIAA0881; PSK; PSK1; TAO1; TAO2
Summary	Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity).[UniProtKB/Swiss-Prot Function]

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