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PD-L1 (CD274) (NM_014143) Human Recombinant Protein
CAT＃: TP710227
Purified recombinant protein of Homo sapiens programmed cell death 1 ligand 1(PD-L1/CD274), transcript variant 1, extracellular domain residue (19-238aa) with C-terminal DDK tag, expressed and secreted from insect sf9 cells, 20ug
View other "PD-L1" proteins (19)
|
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CNY 4,020.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | Sf9 |
| Expression cDNA Clone or AA Sequence |
A DNA sequence from TrueORF clone, RC213071, encoding the region(Met-Phe19-Arg238) of Homo sapiens CD274
|
| Tag | C-DDK |
| Predicted MW | 25.2 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_054862 |
| Locus ID | 29126 |
| UniProt ID | Q9NZQ7 |
| Refseq Size | 1553 |
| Cytogenetics | 9p24.1 |
| Refseq ORF | 870 |
| Synonyms | B7-H; B7H1; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1 |
| Summary | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs) |
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| 蛋白相关资源 |
Other Versions
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|---|---|---|---|
| LC415473 | CD274 HEK293T cell transient overexpression lysate (as WB positive control) |
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| LY415473 | Transient overexpression lysate of PD-L1 / CD274 molecule (PD-L1 / CD274) |
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| TP700200 | Purified recombinant protein of Homo sapiens programmed cell death 1 ligand 1(PD-L1/CD274), transcript variant 1, residue 19-239aa, with C-terminal DDK/His tag, expressed in HEK293 cells. |
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|
| TP700201 | Purified recombinant protein of Homo sapiens programmed cell death 1 ligand 1 (PD-L1/CD274), residues 19-239aa, with C-terminal Fc tag, expressed in HEK293 cells. |
CNY 6,650.00 |
|
| TP710226 | Purified recombinant protein of Human CD274 molecule (CD274), residues 19-290aa, with C-terminal DDK tag, expressed in sf9 insect cells |
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| TP720630 | Purified recombinant protein of Human PD-L1 / CD274 molecule (PD-L1 / CD274) |
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| TP721260 | Human PD-L1 Protein (C-Fc-Avi) |
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| TP721261 | Biotinylated Human PD-L1 Protein (C-Fc-Avi) |
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| TP723946 | Human PD-L1 Protein, mFc-His tag |
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| TP724015 | Human PD-L1 Protein, His tag |
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| TP762432 | Purified recombinant protein of Human PD-L1 / CD274 molecule (PD-L1 / CD274), Trp13-Thr239, with N-terminal His tag, expressed in E.coli, 50ug |
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