OGG1 (NM_002542) Human Recombinant Protein
CAT#: TP720109
Recombinant protein of human 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a
View other "OGG1" proteins (11)
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CNY 3,140.00
Cited in 1 publication. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Met1-Gly345
|
Tag | N-GST |
Predicted MW | 65.1 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Supplied as a 0.2 um filtered solution of 20mMTris-HCl,150mMNacl,1mMEDTA,pH8.5. |
Storage | Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
Reference Data | |
RefSeq | NP_002533 |
Locus ID | 4968 |
UniProt ID | O15527 |
Cytogenetics | 3p25.3 |
Synonyms | HMMH; HOGG1; MUTM; OGH1 |
Summary | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008] |
Protein Families | Druggable Genome |
Protein Pathways | Base excision repair |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells
,Chen, X;Song, L;Hou, Y;Li, F;,
Oncol. Rep.
,PubMed ID 30431140
[OGG1]
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC413811 | OGG1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
LC413813 | OGG1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC413815 | OGG1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC413816 | OGG1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LC413835 | OGG1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY413811 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2a |
CNY 4,840.00 |
|
LY413813 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2b |
CNY 3,080.00 |
|
LY413815 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2d |
CNY 3,080.00 |
|
LY413816 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2e |
CNY 3,080.00 |
|
LY413835 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1b |
CNY 3,080.00 |
|
TP760967 | Purified recombinant protein of Human 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2a, full length, with N-terminal HIS tag, expressed in E. coli, 50ug |
CNY 2,040.00 |