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CD33 (NM_001772) Human Recombinant Protein
CAT＃: TP720665
Purified recombinant protein of Human CD33 molecule (CD33), transcript variant 1
View other "CD33" proteins (13)
|
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CNY 3,140.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence |
Asp18-His259
|
| Tag | C-hFc&His |
| Predicted MW | 55.01 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a 0.2 um filtered solution of PBS, 5% Trehalose, 0.01%Tween 80, pH7.2 |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
| Reference Data | |
| RefSeq | NP_001763 |
| Locus ID | 945 |
| UniProt ID | P20138 |
| Refseq Size | 1466 |
| Cytogenetics | 19q13.41 |
| Refseq ORF | 1092 |
| Synonyms | p67; SIGLEC-3; SIGLEC3 |
| Summary | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).[UniProtKB/Swiss-Prot Function] |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Hematopoietic cell lineage |
Documents
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Resources
| 蛋白相关资源 |
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC400667 | CD33 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421195 | CD33 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC425947 | CD33 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC432863 | CD33 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY400667 | Transient overexpression lysate of CD33 molecule (CD33), transcript variant 1 |
CNY 3,080.00 |
|
| LY421195 | Transient overexpression lysate of CD33 molecule (CD33), transcript variant 2 |
CNY 3,080.00 |
|
| LY425947 | Transient overexpression lysate of CD33 molecule (CD33), transcript variant 2 |
CNY 3,080.00 |
|
| LY432863 | Transient overexpression lysate of CD33 molecule (CD33), transcript variant 3 |
CNY 3,080.00 |
|
| PH307023 | CD33 MS Standard C13 and N15-labeled recombinant protein (NP_001763) |
CNY 19,520.00 |
|
| PH317716 | CD33 MS Standard C13 and N15-labeled recombinant protein (NP_001076087) |
CNY 14,250.00 |
|
| TP307023 | Recombinant protein of human CD33 molecule (CD33), transcript variant 1, 20 µg |
CNY 2,900.00 |
|
| TP317716 | Purified recombinant protein of Homo sapiens CD33 molecule (CD33), transcript variant 2, 20 µg |
CNY 2,900.00 |
|
| TP723960 | Human CD33 Protein, hFc-His Tag |
CNY 5,249.00 |
