NGAL (LCN2) (NM_005564) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Human NGAL, the region of Gln21-Gly198, from gene Accession# NP_005555
Tag	C-His
Predicted MW	22 kDa
Concentration	lot specific
Purity	>95%, as determined by Coomassie stained SDS-PAGE.
Buffer	1 x PBS
Storage	Store at -80°C.
Stability	Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Bioactivity	The BC50 = 1.2 µM, determined by dose dependent binding of the protein (4 µM) with [ Fe3+(DHBA)3] complex.
Endotoxin	Less than 0.01 ng per µg protein as determine by the LAL method
Reference Data
RefSeq	NP_005555
Locus ID	3934
UniProt ID	P80188
Refseq Size	840
Cytogenetics	9q34.11
Refseq ORF	594
Synonyms	24p3; MSFI; NGAL; p25
Summary	This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
Protein Families	Secreted Protein

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